IMPORTANT SAFETY INFORMATION About TRINTELLIX
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Suicidal Thoughts & Actions
TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. TRINTELLIX is not for use in children under 18. Depression or other mental illnesses are the most important causes of suicidal thoughts or actions. Pay close attention to any changes, especially new or sudden changes in mood, behavior, thoughts, or feelings. Call your doctor or get emergency help right away if you have symptoms such as suicidal thoughts or actions, impulsivity, aggressive or violent actions, depression, anxiety or panic attacks, agitation, restlessness, anger, irritability, trouble sleeping, an increase in activity or talking, or other unusual changes in behavior or mood; especially if they are new, worse, or worry you.
Who should not take TRINTELLIX?
Do not start or take TRINTELLIX if you:
- are allergic to vortioxetine or any of the ingredients in TRINTELLIX
- take a Monoamine Oxidase Inhibitor (MAOI)
- have stopped taking an MAOI in the last 14 days
- are being treated with the antibiotic linezolid or intravenous methylene blue
Do not start taking an MAOI for at least 21 days after you stop treatment with TRINTELLIX.
What should I tell my doctor before taking TRINTELLIX?
Before taking TRINTELLIX, tell your doctor:
- about all your medical and other health conditions
- if you are pregnant or plan to become pregnant, since TRINTELLIX may harm your unborn baby. Taking TRINTELLIX during your third trimester may cause your baby to have withdrawal symptoms after birth or to be at increased risk for a serious lung problem at birth. Tell your doctor right away if you become or think you are pregnant while taking TRINTELLIX.
- if you are breastfeeding or plan to breastfeed, since it is not known if TRINTELLIX passes into your breast milk
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, since TRINTELLIX and some medicines may cause serious side effects (or may not work as well) when taken together. Especially tell your doctor if you take: medicines for migraine headache called triptans; tricyclic antidepressants; opioids (such as fentanyl and tramadol); lithium; tryptophan; buspirone; St. John’s Wort; medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin; and diuretics.
What are the possible side effects of TRINTELLIX?
TRINTELLIX may cause serious side effects, including:
- Serotonin syndrome: A potentially life‐threatening problem that can happen when you take TRINTELLIX with certain other medicines. Call your doctor or go to the nearest emergency room right away if you have any of the following signs and symptoms of serotonin syndrome: agitation; seeing or hearing things that are not real; confusion; coma; fast heart beat; changes in blood pressure; dizziness; sweating; flushing; high body temperature; shaking, stiff muscles, or muscle twitching; loss of coordination; seizures; nausea, vomiting, diarrhea.
- Increased risk of bleeding: Taking TRINTELLIX with aspirin, NSAIDs, warfarin or blood thinners may add to this risk. Tell your doctor right away about any unusual bleeding or bruising.
- Manic episodes: Manic episodes may happen in people with bipolar disorder who take TRINTELLIX. Symptoms may include: greatly increased energy; racing thoughts; unusually grand ideas; talking more or faster than usual; severe problems sleeping; reckless behavior; excessive happiness or irritability.
- Discontinuation syndrome: Suddenly stopping TRINTELLIX may cause you to have serious side effects including: nausea; sweating; changes in your mood; irritability and agitation; dizziness; electric shock feeling; tremor; anxiety; confusion; headache; tiredness; problems sleeping; hypomania; ringing in your ears; seizures.
- Eye problems: TRINTELLIX may cause a type of eye problem called angle-closure glaucoma in people with certain other eye conditions. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. Call your doctor if you have eye pain, changes in your vision, or swelling or redness in or around the eye.
- Low levels of salt (sodium) in your blood: Low sodium levels in your blood that may be serious and may cause death can happen during treatment with TRINTELLIX. Elderly people and people who take certain medicines may be at a greater risk for developing low sodium levels in your blood. Signs and symptoms may include headache; difficulty concentrating; memory changes; confusion; weakness and unsteadiness on your feet which can lead to falls. In more severe or more sudden cases, signs and symptoms include: seeing or hearing things that are not real; fainting; seizures; coma; stopping breathing.
- Sexual problems: Taking antidepressants like TRINTELLIX may cause sexual problems. Symptoms in males may include: delayed ejaculation or inability to have an ejaculation, decreased sex drive, or problems getting or keeping an erection. Symptoms in females may include: decreased sex drive, or delayed orgasm or inability to have an orgasm. Talk to your healthcare provider if you develop any changes in your sexual function or if you have any questions or concerns about sexual problems during treatment with TRINTELLIX.
The most common side effects of TRINTELLIX include:
- nausea
- constipation
- vomiting
These are not all the possible side effects of TRINTELLIX. Tell your doctor if you have any side effect that bothers you or does not go away.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
What is TRINTELLIX (vortioxetine)?
TRINTELLIX is a prescription medicine used in adults to treata certain type of depression called Major Depressive Disorder (MDD).
There is a pregnancy registry for females who are exposed to antidepressants during pregnancy. The purpose of the registry is to collect information about the health of females exposed to antidepressants and their babies. If you become pregnant during treatment with TRINTELLIX, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visiting online at https://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/antidepressants/
For additional Important Safety Information, click here for Medication Guide, and discuss with your doctor.
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SCROLL FOR FULL MEDICATION GUIDE
MEDICATION GUIDE
TRINTELLIX (trin’-TELL-ix)
(vortioxetine)
Tablets
What is the most important information I should know about TRINTELLIX?
TRINTELLIX can cause serious side effects, including:
- Increased risk of suicidal thoughts and actions. TRINTELLIX and other antidepressant medicines may increase suicidal thoughts and actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. TRINTELLIX is not for use in children.
- Depression or other mental illnesses are the most important causes of suicidal thoughts or actions.
How can I watch for and try to prevent suicidal thoughts and actions?
- Pay close attention to any changes, especially sudden changes in mood, behavior, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed.
- Call your healthcare provider right away to report new or sudden changes in mood, behavior, thoughts, or feelings or if you develop suicidal thoughts or actions.
- Keep all follow-up visits with your healthcare provider as scheduled. Call your healthcare provider between visits as needed, especially if you have concerns about symptoms.
Call your healthcare provider or get emergency help right away if you have any of the following symptoms, especially if they are new, worse, or worry you:
- attempts to commit suicide
- thoughts about suicide or dying
- feeling agitated, restless, angry or irritable
- other unusual changes in behavior or mood
- acting on dangerous impulses
- new or worse depression
- trouble sleeping
- acting aggressive or violent
- new or worse anxiety or panic attacks
- an increase in activity or talking more than what is normal for you
What is TRINTELLIX?
TRINTELLIX is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD).
Do not take TRINTELLIX if you:
- are allergic to vortioxetine or any of the ingredients in TRINTELLIX. See the end of this Medication Guide for a complete list of ingredients in TRINTELLIX
- take a Monoamine Oxidase Inhibitor (MAOI)
- have stopped taking an MAOI in the last 14 days
- are being treated with the antibiotic linezolid or intravenous methylene blue
Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI or one of these medicines, including the antibiotic linezolid or intravenous methylene blue.
Do not start TRINTELLIX if you stopped taking an MAOI in the last 14 days.
Do not start taking an MAOI for at least 21 days after you stop treatment with TRINTELLIX.
Before taking TRINTELLIX, tell your healthcare provider about all your medical conditions, including if you:
- have or had seizures or convulsions
- have or had bleeding problems
- have, or have a family history of, bipolar disorder, mania or hypomania
- have high pressure in the eye (glaucoma)
- have low sodium levels in your blood
- are pregnant or plan to become pregnant. TRINTELLIX may harm your unborn baby. Taking TRINTELLIX during your third trimester of pregnancy may cause your baby to have withdrawal symptoms after birth or may cause your baby to be at increased risk for a serious lung problem at birth. Talk to your healthcare provider about the risks to you and your unborn or newborn baby if you take TRINTELLIX during pregnancy.
- Tell your healthcare provider right away if you become pregnant or think you are pregnant during treatment with TRINTELLIX.
- There is a pregnancy registry for females who are exposed to TRINTELLIX during pregnancy. The purpose of the registry is to collect information about the health of females exposed to TRINTELLIX and their baby. If you become pregnant during treatment with TRINTELLIX, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visit online at https://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/antidepressants/.
- are breastfeeding or plan to breastfeed. It is not known if TRINTELLIX passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with TRINTELLIX.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
TRINTELLIX and some other medicines may affect each other causing possible serious side effects. TRINTELLIX may affect the way other medicines work and other medicines may affect the way TRINTELLIX works.
Especially tell your healthcare provider if you take:
- medicines used to treat migraine headache called triptans
- tricyclic antidepressants
- fentanyl
- lithium
- tramadol
- tryptophan
- buspirone
- St. John’s Wort
- medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin
- diuretics
Ask your healthcare provider if you are not sure if you are taking any of these medicines. Your healthcare provider can tell you if it is safe to take TRINTELLIX with your other medicines.
Do not start or stop any other medicines during treatment with TRINTELLIX without talking to your healthcare provider first. Stopping TRINTELLIX suddenly may cause you to have serious side effects. See, “What are the possible side effects of TRINTELLIX?"
Know the medicines you take. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine.
How should I take TRINTELLIX?
- Take TRINTELLIX exactly as your healthcare provider tells you to take it. Your healthcare provider may need to change the dose of TRINTELLIX until it is the right dose for you.
- Take TRINTELLIX 1 time each day.
- TRINTELLIX may be taken with or without food.
- If you take too much TRINTELLIX, call your poison control center at 1-800-222-1222 or go to the nearest hospital emergency room right away.
What are the possible side effects of TRINTELLIX?
TRINTELLIX may cause serious side effects, including:
- See, “What is the most important information I should know about TRINTELLIX?”
- Serotonin syndrome.A potentially life-threatening problem called serotonin syndrome can happen when you take TRINTELLIX with certain other medicines. See, “Who should not take TRINTELLIX?” Call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the following signs and symptoms of serotonin syndrome:
- agitation
- seeing or hearing things that are not real (hallucinations)
- confusion
- coma
- fast heart beat
- changes in blood pressure
- dizziness
- sweating
- flushing
- high body temperature (hyperthermia)
- shaking (tremors), stiff muscles, or muscle twitching
- loss of coordination
- seizures
- nausea, vomiting, diarrhea
- Increased risk of bleeding.Taking TRINTELLIX with aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), warfarin or blood thinners may add to this risk. Tell your healthcare provider right away about any unusual bleeding or bruising.
- Manic episodes. Manic episodes may happen in people with bipolar disorder who take TRINTELLIX. Symptoms may include:
- greatly increased energy
- racing thoughts
- unusually grand ideas
- talking more or faster than usual
- severe problems sleeping
- reckless behavior
- excessive happiness or irritability
- Discontinuation syndrome. Suddenly stopping TRINTELLIX may cause you to have serious side effects. Your healthcare provider may want to decrease your dose slowly. Symptoms may include:
- nausea
- sweating
- changes in your mood
- irritability and agitation
- dizziness
- electric shock feeling(paresthesia)
- tremor
- anxiety
- confusion
- headache
- tiredness
- problems sleeping
- hypomania
- ringing in your ears (tinnitus)
- seizures
- Eye problems (angle-closure glaucoma). TRINTELLIX may cause a type of eye problem called angle-closure glaucoma in people with certain other eye conditions. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. Call your healthcare provider if you have eye pain, changes in your vision, or swelling or redness in or around the eye.
- Low levels of sodium in your blood (hyponatremia). Low sodium levels in your blood that may be serious and may cause death, can happen during treatment with TRINTELLIX. Elderly people and people who take certain medicines may be at a greater risk for developing low sodium levels in your blood. Signs and symptoms may include:
- headache
- difficulty concentrating
- memory changes
- confusion
- weakness and unsteadiness on your feet which can lead to falls
- seeing or hearing things that are not real (hallucinations)
- fainting
- seizures
- coma
- stopping breathing (respiratory arrest)
- Sexual problems (dysfunction).
Taking TRINTELLIX may cause sexual problems.
Symptoms in males may include:- Delayed ejaculation or inability to have an ejaculation
- Decreased sex drive
- Problems getting or keeping an erection
Symptoms in females may include:
- Decreased sex drive
- Delayed orgasm or inability to have an orgasm
Talk to your healthcare provider if you develop any changes in your sexual function or if you have any questions or concerns about sexual problems during treatment with TRINTELLIX. There may be treatments your healthcare provider can suggest.
The most common side effects of TRINTELLIX include nausea, constipation, vomiting.
These are not all the possible side effects of TRINTELLIX.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should I store TRINTELLIX?
- Store TRINTELLIX at room temperature between 68°F to 77°F (20°C to 25°C).
- Keep TRINTELLIX and all medicines out of the reach of children.
General information about the safe and effective use of TRINTELLIX.
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not take TRINTELLIX for a condition for which it was not prescribed. Do not give TRINTELLIX to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about TRINTELLIX that is written for healthcare professionals.
What are the ingredients in TRINTELLIX?
Active ingredient: vortioxetine hydrobromide
Inactive ingredients: mannitol, microcrystalline cellulose, hydroxypropyl cellulose, sodium starch glycolate, magnesium stearate and film coating consisting of hypromellose, titanium dioxide, polyethylene glycol 400, iron oxide red (5 mg and 20 mg) and iron oxide yellow (10 mg)
Distributed and Marketed by:
Takeda Pharmaceuticals America, Inc. Lexington, MA 02421
Marketed by: Lundbeck, Deerfield, IL 60015
TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc.
All other trademarks are the property of their respective owners. ©2013-2021 Takeda Pharmaceuticals America, Inc.
For more information, go to www.TRINTELLIX.com or call 1-877-TAKEDA-7 (1-877-825-3327).
This Medication Guide has been approved by the U.S. Food and Drug Administration
Revised: 09/2021
MG-0069
FAQs
What are the major side effects of Trintellix? ›
TRINTELLIX may cause serious side effects, including serotonin syndrome, increased risk of bleeding, hypomania (manic episodes), discontinuation syndrome (side effects if you suddenly stop taking TRINTELLIX), visual problems, low levels of salt in your blood, or sexual problems.
Does Trintellix have rare side effects? ›Although rare, serious side effects are possible from taking Trintellix. Serious side effects that have been reported with Trintellix include: risk of suicidal thoughts and behaviors in children and young adults* serotonin syndrome (high levels of serotonin, a chemical your body produces)
Can vortioxetine make you feel worse? ›Serious side effects shared by Trintellix and Viibryd include: worsening symptoms or suicidal thoughts* serotonin syndrome. sexual side effects such as erectile dysfunction.
Who should not take vortioxetine? ›Do not take vortioxetine if you have taken a monoamine oxidase (MAO) inhibitor (eg, Eldepryl®, Marplan®, Nardil®, Parnate®), methylene blue injection, or linezolid in the past 14 days. Do not start taking a MAO inhibitor within 21 days of stopping vortioxetine.
What is the truth about Trintellix? ›Trintellix can cause many serious side effects, including suicidal thoughts, serotonin syndrome, mania, hypomania, increased bleeding, vision problems, discontinuation syndrome, and low salt levels. Be sure to keep up with your regular health care appointments.
How do you feel on Trintellix? ›When you first start taking Trintellix, you may experience some possible side effects. Some people may experience feeling restless or energized soon after taking a dose, which could lead to trouble sleeping. Here are some other common side effects that people experience when they start taking Trintellix: Nausea.
How long does it take to get used to Trintellix? ›In short-term studies (6-8 weeks) based on a standardized depression rating scale, the therapeutic effect of TRINTELLIX was generally seen starting at week 2, with full effect generally not seen until week 4, or later.
Is Trintellix a strong antidepressant? ›Is Trintellix or Lexapro more effective? A meta-analysis (an analysis of many studies) published in 2018 evaluated 21 antidepressants. Both Trintellix and Lexapro were found to be more effective than other antidepressants. They were both better tolerated than other antidepressants as well.
What can you not take with Trintellix? ›Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Do not take any MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication.
Does vortioxetine cause emotional blunting? ›Conclusion: Vortioxetine 10-20 mg effectively improved emotional blunting, overall functioning, motivation and energy, cognitive performance, and depressive symptoms in patients with MDD with partial response to SSRI/SNRI therapy and emotional blunting.
How do you know if Trintellix is working? ›
Some effect from Trintellix should be noticed by most people after two weeks of treatment; however, the full effect of Trintellix treatment may not be seen until week 4 or later.
Is Trintellix stimulating or sedating? ›Trintellix is a prescription medication indicated in the treatment of major depressive disorder. It is classified as a serotonin modulator and stimulator, making it distinct from other antidepressants currently available.
Is vortioxetine a strong antidepressant? ›Vortioxetine is an antidepressant drug suitable for therapy in various types of depression: severe, anxiety-associated, and of elders. It acts equally strong as SNRIs or agomelatine and has favorable effects on cognitive functioning.
Should vortioxetine be taken in the morning or at night? ›Official answer. Trintellix may be taken either in the morning or at night. However, if you find Trintellix makes you restless, energized, or interferes with your sleep when you take it at night, try taking it in the morning instead.
Why is vortioxetine different? ›It is hypothesized that vortioxetine works via blockade of serotonin reuptake; however, vortioxetine is pharmacologically different than other SSRIs because it also works by direct modulation of various serotonin receptors.
Why would a doctor prescribe Trintellix? ›TRINTELLIX (vortioxetine) is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD).
Should I stop taking Trintellix? ›Like all medications that affect serotonin in the brain, Trintellix should not be discontinued abruptly. Although the drug is not addictive, the dose should be gradually decreased over several weeks before stopping to prevent discontinuation symptoms.
What does Trintellix do to the brain? ›Although it's not fully understood, TRINTELLIX is thought to work by enhancing the activity of a neurotransmitter called serotonin in the brain by blocking serotonin reuptake. It also has activities on some of the receptors for this brain chemical. The link between this information and therapeutic benefit is not known.
How long do people stay on Trintellix? ›How long can you take Trintellix? Trintellix is intended for long-term treatment. There are no known problems associated with the long-term use of vortioxetine. It usually takes four to six weeks of antidepressant treatment to relieve depression symptoms.
What are the pros of Vortioxetine? ›Vortioxetine is an SSRI (selective serotonin reuptake inhibitor) and serotonin receptor modulator. This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living.
Does Trintellix affect appetite? ›
Weight gain with Trintellix may be due to Trintellix increasing appetite (or reversing a poor appetite that is the result of untreated major depressive disorder), or because Trintellix has slightly altered a person's hormones and metabolism.
Is Trintellix energizing? ›Effectively treats a variety of mental health conditions such as depression, OCD, and panic disorder. It's more energizing than other antidepressants, so it's good for people who have low energy.
How long should you take vortioxetine? ›You should expect that a course of treatment will last for several months. This is normal and helps to prevent your symptoms from recurring. You should continue to take vortioxetine for at least six months after you feel well again. If you drink alcohol, ask your doctor for advice.
Does Trintellix interfere with sleep? ›Sleepiness, headache, and insomnia (trouble sleeping or falling asleep) also aren't side effects of Trintellix. But you may develop these side effects if you suddenly stop taking Trintellix. (This is referred to as discontinuation syndrome.)
How fast does Trintellix work for anxiety? ›How long does it take for Trintellix to start working? Like other antidepressants, Trintellix does not start working immediately. While it may take 2 weeks to start feeling the benefits of Trintellix, it can often take 4 weeks or longer to feel the full effects of the drug.
Does Trintellix affect memory? ›Vortioxetine (Trintellix™, Brintellix™) is a prescription antipsychotic and antidepressant medication used to treat major depressive disorder in adults. Vortioxetine targets the neurotransmitter serotonin, which can affect mood, memory, and other cognitive functions [1].
Can Trintellix worsen anxiety? ›Serious side effects of Trintellix, as well as their symptoms, may include: Serotonin syndrome (having too much of the chemical serotonin in your body). Symptoms can include: anxiety.
What does Trintellix do to your eyes? ›Eye problems: TRINTELLIX may cause a type of eye problem called angle-closure glaucoma in people with certain other eye conditions. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are.
Does Trintellix cause anger issues? ›Some patients experienced discontinuation symptoms such as headache, muscle tension, mood swings, sudden outbursts of anger, dizziness, and runny nose in the first week of abrupt discontinuation of TRINTELLIX 15 mg/day and 20 mg/day.
Does vortioxetine cause memory loss? ›Chronic treatment with vortioxetine, but not fluoxetine, improved visuospatial memory and reduced depression-like behavior in the forced swim test. This was associated with change in the expression of multiple genes involved in neuronal plasticity.
Does vortioxetine have cognitive effects? ›
Taken together, the MoCA, DSST, CIBIC+ and global CDR assessments suggest vortioxetine treatment was associated with improvements across a range of cognitive domains. This comprises memory, as well as attention, orientation, executive function and concentration.
How do I know if I need to increase my Trintellix? ›The average starting dosage of Trintellix is 10 mg once per day. If the 10 mg dose isn't working to treat your MDD, your doctor may consider increasing your Trintellix dosage to 20 mg per day. If you have side effects, however, your doctor may decrease your dose to 5 mg once per day.
What is the most similar drug to Trintellix? ›Serotonin norepinephrine reuptake inhibitors (SNRIs), such as Effexor XR (venlafaxine), Pristiq (desvenlafaxine), and Cymbalta (duloxetine) SNRIs are another alternative to Trintellix. These antidepressant medications are commonly available in brand-name and generic forms.
What are the benefits of vortioxetine over other antidepressants? ›A peculiar property of vortioxetine is its efficacy on cognitive symptoms of people with MDD. Many randomized clinical studies have confirmed that vortioxetine 5 mg/day enhances performance in cognitive tests more than placebo and other antidepressants [19, 20].
Is vortioxetine better than SSRI? ›In the comparison with SSRIs, we found no significant differences in the efficacy and acceptability of vortioxetine. SSRIs are usually recommended as first-line treatment for MDD. Therefore, direct comparisons of these antidepressants may help to better guide the clinical application of vortioxetine.
Is vortioxetine 10 mg better than 20mg? ›Vortioxetine 20 mg is significantly more effective than vortioxetine 10 mg in patients with MDD, with a similar tolerability profile. In flexible-dose studies, almost half of all patients received 20 mg/day after 1 week and two-thirds received 20 mg/day as their final dosage.
Is vortioxetine a sedating? ›Vortioxetine is a multimodal antidepressant that inhibits 5-HTT and is also a 5-HT3, 5-HT1D, and 5-HT7 receptor antagonist as well as a 5-HT1B partial agonist and a 5-HT1A agonist. Neither insomnia nor sedation has been reported in clinical trials.
Is 5mg of Trintellix enough? ›Common dosages of Trintellix are 10 mg, 15 mg, and 20 mg, taken daily. People who don't tolerate higher doses of Trintellix may need to take a 5-mg dose of the drug. The normal dosage range for Trintellix is 10 mg to 20 mg per day. Your doctor may increase your dosage to help ease your depression symptoms.
Can I stop Trintellix cold turkey? ›Discontinuation syndrome: Suddenly stopping TRINTELLIX may cause you to have serious side effects including: nausea; sweating; changes in your mood; irritability and agitation; dizziness; electric shock feeling; tremor; anxiety; confusion; headache; tiredness; problems sleeping; hypomania; ringing in your ears; ...
Is Trintellix worth taking? ›Trintellix has an average rating of 6.0 out of 10 from a total of 1,031 reviews on Drugs.com. 47% of reviewers reported a positive experience, while 34% reported a negative experience.
Should Trintellix be taken in the morning or night? ›
Official answer. Trintellix may be taken either in the morning or at night. However, if you find Trintellix makes you restless, energized, or interferes with your sleep when you take it at night, try taking it in the morning instead.
What not to take with Trintellix? ›Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Do not take any MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication.
Is it hard to stop Trintellix? ›Like all medications that affect serotonin in the brain, Trintellix should not be discontinued abruptly. Although the drug is not addictive, the dose should be gradually decreased over several weeks before stopping to prevent discontinuation symptoms. The most common Trintellix discontinuation symptoms are: Nausea.
Does Trintellix affect weight? ›Trials report Trintellix had no significant effect on body weight. Most trials were of 6 to 8 weeks duration, and one trial was for six months. However some reports of weight gain have been reported since the product was first approved, outside of a clinical trial setting.
When should I stop taking Trintellix? ›Do not stop taking vortioxetine, even when you feel better. With input from you, your health care provider will assess how long you will need to take the medicine. Missing doses of vortioxetine may increase your risk for relapse in your symptoms.