Possible Side Effects | TRINTELLIX (vortioxetine) (2023)

FAQs

What are the major side effects of Trintellix? ›

TRINTELLIX may cause serious side effects, including serotonin syndrome, increased risk of bleeding, hypomania (manic episodes), discontinuation syndrome (side effects if you suddenly stop taking TRINTELLIX), visual problems, low levels of salt in your blood, or sexual problems.

Although rare, serious side effects are possible from taking Trintellix. Serious side effects that have been reported with Trintellix include: risk of suicidal thoughts and behaviors in children and young adults* serotonin syndrome (high levels of serotonin, a chemical your body produces)

Serious side effects shared by Trintellix and Viibryd include: worsening symptoms or suicidal thoughts* serotonin syndrome. sexual side effects such as erectile dysfunction.

Do not take vortioxetine if you have taken a monoamine oxidase (MAO) inhibitor (eg, Eldepryl®, Marplan®, Nardil®, Parnate®), methylene blue injection, or linezolid in the past 14 days. Do not start taking a MAO inhibitor within 21 days of stopping vortioxetine.

Trintellix can cause many serious side effects, including suicidal thoughts, serotonin syndrome, mania, hypomania, increased bleeding, vision problems, discontinuation syndrome, and low salt levels. Be sure to keep up with your regular health care appointments.

When you first start taking Trintellix, you may experience some possible side effects. Some people may experience feeling restless or energized soon after taking a dose, which could lead to trouble sleeping. Here are some other common side effects that people experience when they start taking Trintellix: Nausea.

In short-term studies (6-8 weeks) based on a standardized depression rating scale, the therapeutic effect of TRINTELLIX was generally seen starting at week 2, with full effect generally not seen until week 4, or later.

Is Trintellix or Lexapro more effective? A meta-analysis (an analysis of many studies) published in 2018 evaluated 21 antidepressants. Both Trintellix and Lexapro were found to be more effective than other antidepressants. They were both better tolerated than other antidepressants as well.

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Do not take any MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication.

Conclusion: Vortioxetine 10-20 mg effectively improved emotional blunting, overall functioning, motivation and energy, cognitive performance, and depressive symptoms in patients with MDD with partial response to SSRI/SNRI therapy and emotional blunting.

How do you know if Trintellix is working? ›

Some effect from Trintellix should be noticed by most people after two weeks of treatment; however, the full effect of Trintellix treatment may not be seen until week 4 or later.

Trintellix is a prescription medication indicated in the treatment of major depressive disorder. It is classified as a serotonin modulator and stimulator, making it distinct from other antidepressants currently available.

Vortioxetine is an antidepressant drug suitable for therapy in various types of depression: severe, anxiety-associated, and of elders. It acts equally strong as SNRIs or agomelatine and has favorable effects on cognitive functioning.

Official answer. Trintellix may be taken either in the morning or at night. However, if you find Trintellix makes you restless, energized, or interferes with your sleep when you take it at night, try taking it in the morning instead.

It is hypothesized that vortioxetine works via blockade of serotonin reuptake; however, vortioxetine is pharmacologically different than other SSRIs because it also works by direct modulation of various serotonin receptors.

TRINTELLIX (vortioxetine) is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD).

Like all medications that affect serotonin in the brain, Trintellix should not be discontinued abruptly. Although the drug is not addictive, the dose should be gradually decreased over several weeks before stopping to prevent discontinuation symptoms.

Although it's not fully understood, TRINTELLIX is thought to work by enhancing the activity of a neurotransmitter called serotonin in the brain by blocking serotonin reuptake. It also has activities on some of the receptors for this brain chemical. The link between this information and therapeutic benefit is not known.

How long can you take Trintellix? Trintellix is intended for long-term treatment. There are no known problems associated with the long-term use of vortioxetine. It usually takes four to six weeks of antidepressant treatment to relieve depression symptoms.

Vortioxetine is an SSRI (selective serotonin reuptake inhibitor) and serotonin receptor modulator. This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living.

Does Trintellix affect appetite? ›

Weight gain with Trintellix may be due to Trintellix increasing appetite (or reversing a poor appetite that is the result of untreated major depressive disorder), or because Trintellix has slightly altered a person's hormones and metabolism.

Effectively treats a variety of mental health conditions such as depression, OCD, and panic disorder. It's more energizing than other antidepressants, so it's good for people who have low energy.

You should expect that a course of treatment will last for several months. This is normal and helps to prevent your symptoms from recurring. You should continue to take vortioxetine for at least six months after you feel well again. If you drink alcohol, ask your doctor for advice.

Sleepiness, headache, and insomnia (trouble sleeping or falling asleep) also aren't side effects of Trintellix. But you may develop these side effects if you suddenly stop taking Trintellix. (This is referred to as discontinuation syndrome.)

How long does it take for Trintellix to start working? Like other antidepressants, Trintellix does not start working immediately. While it may take 2 weeks to start feeling the benefits of Trintellix, it can often take 4 weeks or longer to feel the full effects of the drug.

Vortioxetine (Trintellix™, Brintellix™) is a prescription antipsychotic and antidepressant medication used to treat major depressive disorder in adults. Vortioxetine targets the neurotransmitter serotonin, which can affect mood, memory, and other cognitive functions [1].

Serious side effects of Trintellix, as well as their symptoms, may include: Serotonin syndrome (having too much of the chemical serotonin in your body). Symptoms can include: anxiety.

Eye problems: TRINTELLIX may cause a type of eye problem called angle-closure glaucoma in people with certain other eye conditions. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are.

Some patients experienced discontinuation symptoms such as headache, muscle tension, mood swings, sudden outbursts of anger, dizziness, and runny nose in the first week of abrupt discontinuation of TRINTELLIX 15 mg/day and 20 mg/day.

Chronic treatment with vortioxetine, but not fluoxetine, improved visuospatial memory and reduced depression-like behavior in the forced swim test. This was associated with change in the expression of multiple genes involved in neuronal plasticity.

Does vortioxetine have cognitive effects? ›

Taken together, the MoCA, DSST, CIBIC+ and global CDR assessments suggest vortioxetine treatment was associated with improvements across a range of cognitive domains. This comprises memory, as well as attention, orientation, executive function and concentration.

The average starting dosage of Trintellix is 10 mg once per day. If the 10 mg dose isn't working to treat your MDD, your doctor may consider increasing your Trintellix dosage to 20 mg per day. If you have side effects, however, your doctor may decrease your dose to 5 mg once per day.

Serotonin norepinephrine reuptake inhibitors (SNRIs), such as Effexor XR (venlafaxine), Pristiq (desvenlafaxine), and Cymbalta (duloxetine) SNRIs are another alternative to Trintellix. These antidepressant medications are commonly available in brand-name and generic forms.

A peculiar property of vortioxetine is its efficacy on cognitive symptoms of people with MDD. Many randomized clinical studies have confirmed that vortioxetine 5 mg/day enhances performance in cognitive tests more than placebo and other antidepressants [19, 20].

In the comparison with SSRIs, we found no significant differences in the efficacy and acceptability of vortioxetine. SSRIs are usually recommended as first-line treatment for MDD. Therefore, direct comparisons of these antidepressants may help to better guide the clinical application of vortioxetine.

Vortioxetine 20 mg is significantly more effective than vortioxetine 10 mg in patients with MDD, with a similar tolerability profile. In flexible-dose studies, almost half of all patients received 20 mg/day after 1 week and two-thirds received 20 mg/day as their final dosage.

Vortioxetine is a multimodal antidepressant that inhibits 5-HTT and is also a 5-HT₃, 5-HT_1D, and 5-HT₇ receptor antagonist as well as a 5-HT_1B partial agonist and a 5-HT_1A agonist. Neither insomnia nor sedation has been reported in clinical trials.

Common dosages of Trintellix are 10 mg, 15 mg, and 20 mg, taken daily. People who don't tolerate higher doses of Trintellix may need to take a 5-mg dose of the drug. The normal dosage range for Trintellix is 10 mg to 20 mg per day. Your doctor may increase your dosage to help ease your depression symptoms.

Discontinuation syndrome: Suddenly stopping TRINTELLIX may cause you to have serious side effects including: nausea; sweating; changes in your mood; irritability and agitation; dizziness; electric shock feeling; tremor; anxiety; confusion; headache; tiredness; problems sleeping; hypomania; ringing in your ears; ...

Trintellix has an average rating of 6.0 out of 10 from a total of 1,031 reviews on Drugs.com. 47% of reviewers reported a positive experience, while 34% reported a negative experience.

Should Trintellix be taken in the morning or night? ›

Official answer. Trintellix may be taken either in the morning or at night. However, if you find Trintellix makes you restless, energized, or interferes with your sleep when you take it at night, try taking it in the morning instead.

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Do not take any MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication.

Like all medications that affect serotonin in the brain, Trintellix should not be discontinued abruptly. Although the drug is not addictive, the dose should be gradually decreased over several weeks before stopping to prevent discontinuation symptoms. The most common Trintellix discontinuation symptoms are: Nausea.

Trials report Trintellix had no significant effect on body weight. Most trials were of 6 to 8 weeks duration, and one trial was for six months. However some reports of weight gain have been reported since the product was first approved, outside of a clinical trial setting.

Do not stop taking vortioxetine, even when you feel better. With input from you, your health care provider will assess how long you will need to take the medicine. Missing doses of vortioxetine may increase your risk for relapse in your symptoms.